Hypersensitivity Research Today is a free monthly online journal that collates and summarizes the latest research about Hypersensitivity, including details on allergens, asthma, syndromes, skin tests, immune responses.

Decreased hypersensitivity reactions with carboplatin-pegylated liposomal doxorubicin compared to carboplatin-paclitaxel combination: analysis from the GCIG CALYPSO relapsing ovarian cancer trial.

Joly F, Ray-Coquard I, Fabbro M, Donoghoe M, Boman K, Sugimoto A, Vaughan M, Reinthaller A, Vergote I, Ferrandina G, Dell'Anna T, Huober J, Pujade-Lauraine E

Centre François Baclesse, Medical Oncology Department, Caen, France. f.joly@baclesse.fr

Published 18 July 2011 in Gynecol Oncol, 122(2): 226-32.
Full-text of this article is available online (may require subscription).

Articles on Hypersensitivity published 27 June 2011:

Steroid hormone hypersensitivity: clinical presentation and management.   Fertil Steril, 95(8): 2571-3.

Hypersensitivity to estrogens and progestogens is often undiagnosed. The condition has many manifestations, including premenstrual syndrome, dysmenorrhea, and impaired fertility. Diagnosis is confirmed by skin testing for inflammatory responses to small doses of the hormone, and desensitization with small doses of the hormone is the most appropriate form of management. [Abstract] [Full-text]

Articles on Hypersensitivity published 20 June 2011:

Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases.   Immunol Rev, 242(1): 128-43.

Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell ... [Abstract] [Full-text]

A study on the immunological basis of the dissociation between type I-hypersensitivity skin reactions to Blomia tropicalis antigens and serum anti-B. tropicalis IgE antibodies.   BMC Immunol, 12(1): 34.

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Articles on Hypersensitivity published 17 June 2011:

The cutaneous and systemic manifestations of azathioprine hypersensitivity syndrome.   J Am Acad Dermatol, 65(1): 184-91.

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High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin.   Int J Clin Oncol, 16(3): 244-9.

[Abstract] [Full-text]

Articles on Hypersensitivity published 15 June 2011:

IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production.   J Invest Dermatol, 131(7): 1513-20.

IL-21 regulates activation, proliferation, and differentiation of various immune cells. We have previously shown that exogenous IL-21 administration reduces allergic reactions in mouse models of anaphylaxis and allergic rhinitis. However, the effects of IL-21 in allergic cutaneous reactions remain unclear. In this study, we examined the effects of IL-21 in a mouse model of the IgE-mediated cutaneous immediate hypersensitivity reaction (IHR). We also investigated the mechanism of IL-21-induced ... [Abstract] [Full-text]

Articles on Hypersensitivity published 7 June 2011:

Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model.   Int Arch Allergy Immunol, 155: 90-5.

[Abstract] [Full-text]

Articles on Hypersensitivity published 6 June 2011:

New insights into visceral hypersensitivity--clinical implications in IBS.   Nat Rev Gastroenterol Hepatol, 8(6): 349-55.

A subset of patients with IBS have visceral hypersensitivity and/or somatic hypersensitivity. Visceral hypersensitivity might have use as a clinical marker of IBS and could account for symptoms of urgency for bowel movements, bloating and abdominal pain. The mechanisms that lead to chronic visceral hypersensitivity in patients who have IBS are unclear. However, several working models may be considered, including: nociceptive input from the colon that leads to hypersensitivity; increased ... [Abstract] [Full-text]

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